Elevated Levels of ACTH Can Cause Skin Darkening,as a Result

Question

Elevated levels of ACTH can cause skin darkening,as a result of the ability of ACTH to:
A)Bind to the melanocortin 1 receptor (MC1R).
B)Stimulate cortisol production.
C)Bind to the corticotropin-releasing hormone (CRH)receptor
D)Stimulate adrenal androgen production.
E)Stimulate $\alpha$-melanocyte-stimulating hormone ($\alpha$-MSH)production

Accepted Answer

Elevated levels of ACTH can lead to skin darkening because ACTH can bind to the melanocortin 1 receptor (MC1R), which is involved in regulating skin pigmentation. This activation of the MC1R can result in increased production of melanin, leading to darkening of the skin.