The Binding of Which of the Following SnRNPs to Spliceosome

Question

The binding of which of the following snRNPs to spliceosome requires ATP?
A)U1
B)U2
C)U4
D)U5
E)U6

Accepted Answer

The binding of U2 snRNP to the spliceosome requires ATP. This energy is necessary for the rearrangement of the spliceosome complex and the stabilization of the interaction between U2 snRNP and the branch point sequence in pre-mRNA, which is a critical step in the splicing process.