Under Which of the Following Conditions Does TfR MRNA Degradation

Question

Under which of the following conditions does TfR mRNA degradation take place?
A)conversion of citrate to isocitrate
B)IRE hairpin loop formation
C)aconitase apoprotein binding to IRES
D)low iron concentrations
E)high iron concentrations

Accepted Answer

TfR mRNA degradation occurs under high iron concentrations. When iron levels are high, the iron regulatory protein (IRP) binds to iron, changing its conformation and preventing it from binding to the iron response element (IRE) on the TfR mRNA. This lack of protection leads to the degradation of TfR mRNA, reducing the synthesis of transferrin receptors and thus iron uptake.